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Tiwari, Gaurav
- Recent Advancements in Periodontal Drug Delivery Systems
Abstract Views :187 |
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Authors
Gaurav Tiwari
1,
Ruchi Tiwari
2,
Awani K. Rai
2,
Vachaspati Dubey
2,
Anil Sharma
3,
Pranay Wal
2,
Ankita Wal
2
Affiliations
1 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur 208020, (Uttar Pradesh), IN
2 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur 208020, (Uttar Pradesh), IN
3 Gyan Vihar University, Jaipur, Rajasthan, IN
1 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur 208020, (Uttar Pradesh), IN
2 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti, Kanpur 208020, (Uttar Pradesh), IN
3 Gyan Vihar University, Jaipur, Rajasthan, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 2 (2010), Pagination: 125-132Abstract
Advances in understanding the etiology, epidemiology and microbiology of periodontal pocket flora have revolutionised the therapeutic strategies for the management of periodontal disease progression. The rationale for use of antibiotics in periodontal therapy is based on the concept that bacteria are the primary cause of periodontal diseases and thus treatment should be directed towards controlling the bacterial flora.. The effectiveness of mechanical debridement of plaque and repeated topical and systemic administration of antibacterial agents are limited due to the lack of accessibility to periodontopathic organisms in the periodontal pocket. Systemic administration of drugs leads to therapeutic concentrations at the site of infection, but for short periods of time, forcing repeated dosing for longer periods. Local delivery of antimicrobials has been investigated for the possibility of overcoming the limitations of conventional therapy. The use of sustained release formulations to deliver antibacterials to the site of infection (periodontal pocket) has recently gained interest. This review summarises the recent developments in the field of intra-pocket drug delivery systems and identifies areas where further research may lead to a clinically effective intra-pocket delivery system.
- Chronopharmaceutics:A Clinically Relevant Approach to Drug Delivery
Abstract Views :201 |
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Authors
Affiliations
1 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti Kanpur 208020, (Uttar Pradesh), IN
2 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti Kanpur 208020, (Uttar Pradesh), IN
3 Suresh Gyan Vihar University, Jaipur, Rajasthan, IN
1 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti Kanpur 208020, (Uttar Pradesh), IN
2 Department of Pharmaceutics, Pranveer Singh Institute of Technology, Kalpi Road, Bhauti Kanpur 208020, (Uttar Pradesh), IN
3 Suresh Gyan Vihar University, Jaipur, Rajasthan, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 2 (2010), Pagination: 139-145Abstract
Chronopharmaceutics covers the fundamentals of the various aspects of chronopharmaceutics in the fields of chronobiology, chronogenetics, chronophysiology, chronopathology, chronopharmacology, chronotherapeutics, chronotoxicology and chronobiotics, and chronopharmaceutical drug delivery research. It discusses different and specific controlled-release systems that are triggered by electrics, diffusion, and chemical-activation and concludes with a description of the regulatory issues along with formulation and manufacturing.Due to advances in chronobiology, chronopharmacology, and global market constraints, the traditional goal of pharmaceutics (e.g. design drug delivery systems with a constant drug release rate) is becoming obsolete. However, the major bottleneck in the development of drug delivery systems that match the circadian rhythm (chronopharmaceutical drug delivery systems: ChrDDS) may be the availability of appropriate technology. The last decade has witnessed the emergence of ChrDDS against several diseases. The increasing research interest surrounding ChrDDS may lead to the creation of a new subdiscipline in pharmaceutics known as chronopharmaceutics. This review introduces the concept of chronopharmaceutics, addresses theoretical/formal approaches to this sub-discipline, underscores potential disease-targets, revisits existing technologies and examples of ChrDDS. Future development in chronopharmaceutics may be made at the interface of other emerging disciplines such as system biology and nanomedicine. Such novel and more biological approaches to drug delivery may lead to safer and more efficient disease therapy in the future.Keywords
Chronopharmaceutics, Chronopharmacology, Chronotherapeutics, Drug Delivery, Technologies.- Target Retentive Biodegradable Periodontal Disks for Simultaneous Extended Release of Metronidazole and Doxycycline:Formulation Consideration
Abstract Views :182 |
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Authors
Affiliations
1 Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur, Rajasthan, IN
2 Pranveer Singh Institute of Technology, Kalpi Road Bhauti, Kanpur, (U. P.), IN
1 Department of Pharmaceutics, Jaipur National University, Jagatpura, Jaipur, Rajasthan, IN
2 Pranveer Singh Institute of Technology, Kalpi Road Bhauti, Kanpur, (U. P.), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 62-66Abstract
Buccoadhesive erodible disks of metronidazole and doxycycline were prepared using different bioadhesive polymers along with excipients like magnesium stearate. The purpose of designing the erodible disk was to obviate the need for removal of exhausted device. The optimized disk containing 3% w/w of magnesium stearate along with hydroxypropylmethylcellulose K4M and sodium carboxy methyl cellulose in the ratio of 1:3 was found to release the drug for a period of over 6.0 h without getting dislodged. Maximum in vitro drug release was found to be 94.78% in 6.0-h study. In situ release characteristics were evaluated using a 'flow-through assembly', which simulated the conditions of the human buccal cavity. The drug concentrations in the in situ samples were found to be above minimum inhibitory concentration (MIC) of the drug. The bioadhesive performance and the surface pH of the disks were satisfactory. Metronidazole and Doxycycline disks were tested against microorganisms commonly found in oro-dental infections namely Staphylococcus aureus, Escherichia coli and Streptococcus mutans. The disk as well as the in situ samples showed inhibition of growth of microorganisms. Thus a stable, extended release periodontal disks containing both metronidazole and doxycycline with satisfactory bioadhesion was developed.
Keywords
Bioadhesive Polymers, Extended Release, Metronidazole, Doxycycline, Periodontal Diseases.- Linking Self Efficacy and Workplace Spiritualıty in IT (Information Technology) Industry Using Structural Equation Modelling
Abstract Views :204 |
PDF Views:79
Authors
Affiliations
1 School of Management, Doon University, Dehradun - 248001, Uttarakhand, IN
2 School of Management, Doon University, Dehradun 248001, Uttarakhand, IN
1 School of Management, Doon University, Dehradun - 248001, Uttarakhand, IN
2 School of Management, Doon University, Dehradun 248001, Uttarakhand, IN
Source
SAMVAD: International Journal of Management, Vol 14 (2017), Pagination: 34-39Abstract
Business scenario is changing rapidly nowadays and competition is increasing both, internally and externally in organization due to globalization, workload and mergers and acquisitions. To sustain and overcome, it is inevitable for organizations to have delighted, focused, self motivated and self directed employees. But organizations in present time are filled with employees having low inner zeal and diluted compassion. These employees are not finding meaning in work and don't feel connected to their work at the same time. It is now a herculean task for organization to enhance and improvise employees' self efficacy and workplace spirituality. This paper investigates and validates the conceptualized linkage between self efficacy and workplace spirituality in IT industry using advanced analytic techniques. Confirmatory factor analysis and structural equation model was applied for hypothesis testing. The result indicates a significant positive linkage between workplace spirituality and self efficacy with age and experience as moderator. This study attempts to provide an idea to the organization to enhance employee's efficacy through increased workplace spirituality and a conceptual idea also for frequently changing environment.Keywords
Confirmatory Factor Analysis, Experience, Self-Efficacy, Workplace Spirituality.Full Text
References
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- Ethical Behavior Through the Lens of Workplace Spirituality:A Review Agenda
Abstract Views :235 |
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Authors
Affiliations
1 Doon University, Dehradun, Uttrakhand, IN
1 Doon University, Dehradun, Uttrakhand, IN
Source
International Journal of Business Ethics in Developing Economies, Vol 7, No 1 (2018), Pagination: 23-31Abstract
Workplace spirituality has now become an integral part of behavioral practices. Over the last decade, researchers have been taking interest in understanding workplace spirituality in organizations. The frequent discussion about spirituality at the workplace has also fortified the perception of ethical behavior among individuals. Ethical behavior among employees has been widely advanced by the spiritual values, which affect the work environments and organizational culture at large. This study reflects upon the relationship and interconnectedness between spirituality and ethical behavior in organizations. It also aims at suggesting ways as to how spirituality can be a driving factor for ethical behavior among individuals in organizations. Extensive literature review on the study has been conducted to gain insights on workplace spirituality and ethics. The study inferred that integrating various factors like leadership, culture, organizational citizenship behavior in the work environment might augment spirituality and ethical behavior at workplace.Keywords
Workplace Spirituality, Ethics, Organizational Culture, Values.References
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